Allopurinol - Chronic Gout Treatment: What You need to know About Allopurinol
Allopurinol (which goes by the brand names Aloprim and Zyloprim) is a drug that belongs to a class of drugs called xanthine oxidase inhibitors. Allopurinol is prescribed for the treatment of chronic gout and also is employed to prevent rather than treat gout attacks.
The medicine works by blocking uric acid production. Uric acid is a waste product usually present in the blood as a result of the breakdown of purines. Excessive amounts of uric acid can cause crystals to form in the joints, which can lead to gout.
When is Allopurinol Prescribed?
Allopurinol is prescribed to prevent chronic gout attacks, manage high uric acid levels caused by cancer medications, as well as handle kidney stones. Additionally, there are a number of off-label uses for which your doctor may prescribe allopurinol.
What is the Accessibility to Allopurinol?
Allopurinol is available as a 100 mg. capsule. It is taken a few times daily, usually carrying out a meal.
Are There Any Kind of Special Guidelines Concerning How to Take Allopurinol?
Patients are advised to follow the prescribing instructions precisely. It is common for the starting dose of allopurinol to become low and gradually increased. Noticeable benefit from taking allopurinol may take months. In fact, during the first few months of use, the treatment may actually increase the number of gout attacks. Eventually, allopurinol will prevent gout attacks. In the interim, colchicine may be prescribed as well. Do not stop taking allopurinol even if you're feeling well.
Are There Patients Who Should Not Take Allopurinol?
Patients who are known to be allergic to allopurinol obviously should not take the medication. Patients taking any of the following medications should notify their particular doctor simply because they may require a dose adjustment:
AmoxicillinAmpicillinCoumadinCytoxanPurinetholDiabineseDiureticsImmunosuppressantsOther gout medicationsWhat common side effects can occur with allopurinol?
- Allopurinol can cause upset stomach, looseness of the bowels, and drowsiness.
- Rash is one of the more common side effects and can occur even with months or years of therapy.
Are There More Severe Side Effects Related to Allopurinol?
Uncommon side effects that are more serious if they occur include:
Hypersensitivy reactionsItchingBlood inside pee or pain when urinatingEye irritationSwelling around mouth or perhaps lipsSigns of infectionLoss of urge for food or unexpected weight lossWhat special safety measures and precautions are associated with allopurinol?
- Patients are advised to drink 8 glasses of water daily (unless a doctor instructs otherwise).
- Alcoholic drinks may decrease the effectiveness of allopurinol.
- Drinks or supplements containing vitamin c may be problematic in large quantities.
- Excessive vitamin C and allopurinol can combine to make urine acidic and also cause kidney stones.
- Patients with kidney problems may need dose adjustment with regard to allopurinol.
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Are There Special Instructions for With Child or Even Nursing Women?
You are with child, breastfeeding, or thinking about becoming pregnant, discuss allopurinol with your doctor. Few reports of allopurinol use during pregnancy exist. Although no adverse fetal outcomes associated with allopurinol have been mentioned in humans, allopurinol should only be used after weighing benefit to the patient as opposed to risk to the fetus.
How is It Determined that Allopurinol is Actually an Effective Treatment?
Certain laboratory tests are periodically ordered which help to determine if the drug is working successfully.
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Chris Randon is a nutritionist specialized in human health, and it is based in Los angeles, Carlifornia.
Domenic is a head content marketing specialist at musclenstress.com, a collection of articles on health issues. In the past, Domenic worked as a post curator for a well-known health site. When he's not writing posts, Domenic enjoys drawing and rock climbing.